You Searched For: GSK-J4+(Free+base)

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GSK-J4 (Free base) 98+%

Supplier: Ambeed

Description: GSK-J4 (Free base) 98+%

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GSK-J4 hydrochloride 95%

Catalog Number: (TS468001000)

Supplier: Thermo Scientific Chemicals

Description: Chemical probes can be used to help establish the
relationship between a molecular target and the broader
biological consequences of modulating that target in cells
or organisms.

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Description: Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride, Purity: 98%, CAS Number: 1797983-09-5, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 10mg

Bisindolylmaleimide I ≥98% (by NMR)

Supplier: Adipogen

Description: Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

Anti-CD72 Mouse Monoclonal Antibody (eFluor® 660) [clone: J4-117]

Catalog Number: (102469-694)

Supplier: Affymetrix, Inc.

Description: 5 to 10^8 cells/test. eFluor®® 660 is a replacement for Alexa Fluor® 647. eFluor®® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.

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Hepatitis C virus (HCV) Recombinant HCV NS3 protease (from E. coli)

Supplier: Anaspec Inc

Description: NS3 protease of hepatitis C virus (HCV), located on the N-terminal domain of HCV NS3, is responsible for the cleavage at the NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites of the nonstructural protein. The HCV NS3 is a chymotrypsin-like serine protease. It requires a cofactor, a 54 amino acid NS4 protein, to reach its optimal activity. The X-ray crystal structure studies show that NS3 forms a tight non-covalent complex with NS4. The NS3/4A protease is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy.

The recombinant HCV NS3/4A protease (genotype 1b, strain: HC-J4; NCBI Accession: AF054247) was expressed in E. Coli. HCV NS3/4A protease is a 217 amino acid fusion protein (22.7 kDa) with NS4A co-factor fused to the N-terminus of NS3 protease domain. Therefore, HCV NS3/4A protease is in active form and the pre-activation by pep4A or pep4AK is not necessary. 5-20 ng of HCV NS3/4A protease is sufficient for FRET-based activity assays (SensoLyte® HCV protease assay).

GSK-J1 (Free acid) 98%

Supplier: Ambeed

Description: 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid, Purity: 98%, CAS Number: 1373422-53-7, Appearance: White to off-white powder or crystals, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 5mg

Anti-CTNNB1 Mouse Monoclonal Antibody [clone: 12F7]

Catalog Number: (10050-142)

Supplier: Enzo Life Sciences

Description: β-Catenin, a vertebrate homologue of Drosophila armadillo encoded by the CTNNB1 gene, performs two functions in the cell: mediating cell-cell adhesion by association between E-cadherin and the cytoskeleton, and acting as a downstream transcriptional activator of Wnt signaling, a key player in such functions as embryonic development, the induction of cell polarity, and the determination of cell fate. In the absence of Wnt signaling, glycogen synthase kinase-3β (GSK-3β) phosphorylates any free β-catenin at the amino terminus. This results in adenomatous polyposis coli tumor suppressor protein (APC)-mediated β-catenin degradation via the ubiquitin-proteosome pathway. Wnt signaling stabilizes β-catenin by inhibiting the activity of GSK-3β and preventing β-catenin degradation. β-catenin forms complexes with DNA-binding proteins such as T-cell factor (Tcf) and lymphocyte-enhancer factor (Lef), which promote expression of a variety of target genes, including c-myc and cyclin D1.

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Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Recombinant Envelope/E2 Protein (His Tag) (from HEK293 Cells)

Catalog Number: (103918-882)

Supplier: Sino Biological

Description: A DNA sequence encoding the Hepatitis C virus (HCV)(serotype 1b,isolate HC-J4E) E (AAC15723.1)(Glu384-Glu661) was expressed with a polyhistidine tag at the C-terminus.

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Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (103480-224)

Supplier: Affymetrix, Inc.

Description: 356] antibody, enables one to distinguish between phosphorylation at the two distinct residues, rather then a combined epitope as detected by 12E8 antibody.

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Hepatitis C virus Envelope Recombinant Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His Tag) (from HEK293 Cells)

Catalog Number: (103664-072)

Supplier: Sino Biological

Description: A DNA sequence encoding the envelope glycoprotein E1 of Hepatitis C virus (subtype 1b, strain HC-J4) (AAC15725.1) (Tyr192-Ile340) was expressed with a polyhistidine tag at the N-terminus.

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