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Supplier: Ambeed
Description: AT7519 hydrochloride ≥98%

Supplier: Adipogen
Description: AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from <lt/>10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.

Supplier: Ambeed
Description: 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide 98+%

Catalog Number: (10118-204)
Supplier: VWR
Description: L-Ornithine hydrochloride grade: reagent CAS Number: 3184-13-2 synonym(s): (S)?-?(+)?-?2, 5-?Diaminopentanoic Acid Hydrochloride, (S)?-?2, 5-?Diaminopentanoic Acid Monohydrochloride, L-Ornithine Monohydrochloride 500g

Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: L-Arginine Hydrochloride, Multi-Compendial
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: Guanidine Hydrochloride, GenAR®
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: Clear, colorless liquid. Suitable for use in biotechnology. GMP manufactured product.
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: L-Arginine Hydrochloride, U.S.P., Multi-Compendial
Catalog Number: (JT4108-07)
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: TRIS Hydrochloride, Ultrapure Bioreagent

Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: White powder.
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: Tested for absence of detectable aldehydes and ammeline. DNase-, RNase-, and protease-free.
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: Tris Hydrochloride 50Kg
Catalog Number: (97061-350)
Supplier: VWR
Description: Suited for purification of nucleic acids or polypeptides from cell sources and inhibition of both RNase and protease activity.

Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: L-Arginine hydrochloride 98.5-101.0% USP, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™

Catalog Number: (JT4126-07)
Supplier: AVANTOR PERFORMANCE MATERIALS US
Description: TRIS Hydrochloride, Biotech Reagent

Supplier: VWR
Description: A protease inhibitor of arginine-selective enzymes like trypsin, kallikrein and thrombin.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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