AT7519 hydrochloride ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride, AT7519 HCl

SYN-1010-M001 SYN-1010-M005 SYN-1010-M010 SYN-1010-M050
102991-322EA 90 USD
102991-322 102991-324 102991-326 102991-328
AT7519 hydrochloride ≥95%
AT7519 hydrochloride

AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from 10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.

Formula: C₁₆H₁₇Cl₂N₅O₂·HCl
MW: 418.7 g/mol
Storage Temperature: Freezer
MDL Number: MFCD14636428
CAS Number: 902135-91-5

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO or ethanol.

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