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Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00012453
Supplier: Strem Chemicals Inc
Description: CAS #: 14852-83-6. Size: 5g.

Catalog Number: (76236-264)
Supplier: Rockland Immunochemical
Description: Human PD-L1 - B7-H1 AccuSignal ELISA Kit


Catalog Number: (76634-556)
Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.


Supplier: Thermo Scientific Chemicals
Catalog Number: (76236-266)
Supplier: Rockland Immunochemical
Description: Mouse PD-L1 - B7-H1 AccuSignal ELISA Kit


Catalog Number: (76163-664)
Supplier: Prosci
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).


Catalog Number: (76163-568)
Supplier: Prosci
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).


Supplier: TCI America
Description: CAS Number: 31277-98-2
MDL Number: MFCD00009880
Molecular Formula: C52H48P4Pd
Molecular Weight: 903.27
Purity/Analysis Method: >96.0% (T)
Form: Crystal
Storage Temperature: >-20°C

SDS

Catalog Number: (103294-704)
Supplier: Novus Biologicals
Description: The PD-1 Antibody (913425) [FITC] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [FITC] has been validated for the following applications: Flow Cytometry.


Supplier: Brandtech
Description: Adapters are required for use with the 25 and 50 ml PD-Tips™ II dispenser tips, allowing them to be attached to the HandyStep® touch and HandyStep® electronic repeating pipettes.

Catalog Number: (10765-106)
Supplier: Prosci
Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.


Supplier: Thermo Scientific Chemicals
Description: Tetrakis(triphenylphosphine)palladium(0) 99%

Supplier: BeanTown Chemical
Description: CAS: 12135-22-7; EC No: 235-219-2; MDL No: MFCD00064599 Powder; Linear Formula: Pd(OH)2; MW: 140.42

SDS

Supplier: Strem Chemicals Inc
Description: CAS #: 7440-05-3. Size: 5g.

Catalog Number: (103407-214)
Supplier: Novus Biologicals
Description: The PD-1 Antibody (J43) [Biotin] from Novus Biologicals is a armenian hamster monoclonal antibody to PD-1. This antibody reacts with mouse. The PD-1 Antibody (J43) [Biotin] has been validated for the following applications: Immunohistochemistry-Frozen.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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