(R)-BI-2536 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: BI-2536, BI 2536, (R)-4-((8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

SYN-1019-M001 SYN-1019-M005 SYN-1019-M010 SYN-1019-M050
102991-392EA 119.08 USD
102991-392 102991-394 102991-396 102991-398
(R)-BI-2536 ≥95%
(R)-BI-2536

Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC(50) values below 1µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases PLK2 and PLK3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers.

Formula: C₂₈H₃₉N₇O₃
MW: 521.7 g/mol
Storage Temperature: Freezer
MDL Number: MFCD10565924
CAS Number: 755038-02-9

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Specification Test Results

Purity >95%
Appearance/Color Solid.
Solubility Soluble in DMSO, Ethanol

SPECIFICATIONS

Environmentally Preferable

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