Print…

You Searched For: (R)-BI-2536


4  results were found

Refine Results Sort by
SearchResultCount:"4"

Sort Results

List View Easy View

Rate These Search Results

Image Unavailable-TS467961000

(R)-BI-2536 95%

Catalog Number: (TS467961000)
Supplier: Thermo Scientific Chemicals
Description: Chemical probes can be used to help establish the relationship between a molecular target and the broader biological consequences of modulating that target in cells or organisms.

New Product


Image Unavailable-76003-124

(R)-BI-2536 ≥97% (by HPLC)

Supplier: Enzo Life Sciences
Description: Potent and selective inhibitor of mammalian Plk1

Image Unavailable-77030-200

(R)-BI-2536 98%

Catalog Number: (77030-200)
Supplier: Ambeed
Description: (R)-BI-2536 98%
Image Unavailable-102991-394

(R)-BI-2536 ≥95%

Supplier: Adipogen
Description: Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC(50) values below 1µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases PLK2 and PLK3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers.

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
1 - 4 of 4
no targeter for Bottom