You Searched For: Diagnostic Biosystems

Catalog Number: (76634-204)

Supplier: Diagnostic Biosystems

Description: The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppeltype zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas. The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt's lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocytepredominance Hodgkin's lymphoma. BCL6 protein is not expressed in BCLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas

Supplier: Diagnostic Biosystems

Description: This antibody recognizes human retinoblastoma gene protein. Rb gene, a prototype of tumor suppressor genes, has been associated with development and/or progression of bladder cancer as well as sarcoma and small cell lung cancer. Functional Rb gene loss has been reported to occur in bladder cancer and osteosarcoma. A significantly poorer tumor-free survival rate was noted for those patients who had a tumor with an altered Rb protein with or without vascular invasion.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.

Supplier: Diagnostic Biosystems

Description: The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin and substance P. CD10 is expressed by a number of hematopoietic cells such as immature T and B cells, B cells of the germinal centers of lymphoid follicles and granulocytes. It also reacts with a variety of non-hematopoietic cells, including epithelial cells in GI tract and kidney tubular. In liver, the bile canaliculi shows a moderate to strong staining. CD10 has been used for the identification and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis. It is also known to be a marker of endometrial stromal cells. It is helpful in differentiating endometrial stromal sarcoma (ESS) from uterine cellular leiomyoma (UCL) and uterine leiomyosarcoma (ULS).

Supplier: Diagnostic Biosystems

Description: CD138, also known as Syndecan-1, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. CD138 expression is found in both hematopoietic and non-hematopoietic cells. In the hematopoietic system, CD138 labels plasma cells. It is an excellent marker for plasmacytic differentiation within the spectrum of hematologic malignancy. Among non-hematolymphoid cells, CD138 reactivity is observed in many types of epithelial cells and stoma cells in both normal and tumor tissues.

Supplier: Diagnostic Biosystems

Description: The antibody is specific against gastrin-containing cells. This anti-body reacts with human gastrin I and human gastrin I fragments. No cross-reactivity was observed with rat gastrin, human big gastrin, human gastrin releasing peptide, sulfated cholecystokinin amide, non-sulfated cholecystokinin amide and cholecystokinin.

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β chain (i.e. in S-100a and S-100b) but not on the α chain of S-100 (i.e. in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.

Supplier: Diagnostic Biosystems

Description: Inhibin is a dimeric glycoprotein hormone from the TGF-β family made of α and β subunits. This antibody recognizes the 32kDa α subunit of human inhibin. Inhibin α is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in fetoplacental unit.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a protein of 57 kDa known as p57Kip2 a cell cycle regulatory mitotic inhibitor. This antibody does not cross-react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and a negative regulator of cell proliferation.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes an uncharacterized antigen present in both adults and fetal normal hepatocytes to produce a distinct granular cytoplasmic staining. This antibody stains majority of hepatocellular carcinomas.

Catalog Number: (99990-062)

Supplier: Diagnostic Biosystems

Description: Washing buffer, 10X Immuno Wash Buffer

Catalog Number: (95025-204)

Supplier: Diagnostic Biosystems

Description: This kit is designed to label specific primary antibodies immunohistochemically on tissue sections. The immunohistochemical protocol defined in this brochure is just a guideline. Depending upon tissue fixation conditions, the primary antibody employed, and the user’s experience, we encourage individual laboratory to optimize its own protocol. These reagents were tested and quality controlled using tissue sections, however, they can also be optimized for cell smears and cytospin preparations. Sufficient reagents are provided to run 50 to 100 tests.

Catalog Number: (99990-830)

Supplier: Diagnostic Biosystems

Description: Anti-GFAP Mouse Monoclonal Antibody [clone: GA5]

Supplier: Diagnostic Biosystems

Description: This antibody is specific to α and γ specific actin isomers from skeletal, cardiac and smooth muscle but does not recognize β and nonsmooth muscle γ actin isomers.

Catalog Number: (95027-202)

Supplier: Diagnostic Biosystems

Description: This kit stains myelin sheath and Nissl substance in paraffin tissue sections