You Searched For: Enzo Life Sciences

Catalog Number: (10051-936)

Supplier: Enzo Life Sciences

Description: Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.

Catalog Number: (10051-980)

Supplier: Enzo Life Sciences

Description: The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

Catalog Number: (10051-978)

Supplier: Enzo Life Sciences

Description: TRAF proteins are multifunctional signal adaptors that are involved in the activation of the kinase cascades which activate c-Jun N-terminal kinase, p38 mitogen activated protein kinase, and the transcription factor NF-κB. Members of the TRAF family form homodimers as well as heterodimers, resulting in extensive diversity and specificity to their function in signal transduction pathways.

Catalog Number: (10050-274)

Supplier: Enzo Life Sciences

Description: Members of the TNF superfamily regulate immune responses and induce apoptosis. Two members of this family were identified and designated BAFF and April, respectively. Three receptors for BAFF were identified; these include: BCMA (B-cell maturation protein), TACI, and BAFF-R. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B-Cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B-Cell associated autoimmune diseases.

Catalog Number: (10050-272)

Supplier: Enzo Life Sciences

Description: BAFF, or B-cell Activating Factor, is a member of the TNF superfamily also known as BLyS (B Lymphocyte Stimulator), TALL-1 (TNF- and ApoLrelated Leukocyte-expressed Ligand), and THANK (TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B-cell activator since it induced B-cell proliferation and immunoglobulin secretion. Three receptors for BAFF were identified and designated TACI, BCMA, and BAFF-R. BAFF and its receptors are essential for B-cell development, survival, and humoral immune responses.

Catalog Number: (10049-852)

Supplier: Enzo Life Sciences

Description: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.

Catalog Number: (10049-874)

Supplier: Enzo Life Sciences

Description: Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.

Catalog Number: (10049-888)

Supplier: Enzo Life Sciences

Description: MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow easier access of CAD, thereby accelerating the degradation of genomic DNA.

Catalog Number: (10050-190)

Supplier: Enzo Life Sciences

Description: Monoclonal Antibody, Primary Antibody, Used in FC with species reactivity to Human, Mouse, Rat, Dog, Bovine, Chicken, Fish, Host: Mouse, Immunogen: Purified HSC70 and HSP70 isolated from human HeLa cells, Isotype: IgG1

Catalog Number: (10050-188)

Supplier: Enzo Life Sciences

Description: The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Supplier: Enzo Life Sciences

Description: For use with GFP-expressing cell lines, as well as cells expressing blue, cyan or yellow fluorescent proteins.

SDS

Catalog Number: (10033-562)

Supplier: Enzo Life Sciences

Description: From cytomegalovirus, strain AD169. Inactivated by 0.2% Triton X-100.

Catalog Number: (10033-554)

Supplier: Enzo Life Sciences

Description: From Clostridium difficile, strain VPI10463

Catalog Number: (10033-558)

Supplier: Enzo Life Sciences

Description: Cell lysate ideal for use as a broad positive control.

Catalog Number: (10033-586)

Supplier: Enzo Life Sciences

Description: From herpes simplex virus type 1. Inactivated by 0.1% Triton X-100.

Catalog Number: (95053-388)

Supplier: Enzo Life Sciences

Description: Glucagon-like peptide 1 (7-36) amide (GLP-1 (7-36) amide) is the principal active form of GLP-1, the other being GLP-1 (7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.