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You Searched For: Z-Gly-Pro-Arg-Mca+Hydrochloride


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Z-Gly-Pro-Arg-Mca Hydrochloride

Supplier: Bachem Americas
Description: Sequence: Z-Gly-Pro-Arg-AMC · HCl

Image Unavailable-M-2350.0005BA

Mca-Lys-Pro-Leu-Gly-Leu-Dap -Ala-Arg-Nh₂

Supplier: Bachem Americas
Description: Sequence: Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂

Image Unavailable-I-1545.0050BA

Boc-Glu(obzl)-Gly-Arg-Mca hydrochloride

Catalog Number: (I-1545.0050BA)
Supplier: Bachem Americas
Description: Sequence: Boc-Glu(OBzl)-Gly-Arg-AMC · HCl
Image Unavailable-M-2455.0001BA

Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ Trifluoroacetate

Catalog Number: (M-2455.0001BA)
Supplier: Bachem Americas
Description: FRET substrate for cathepsin D and E.
Product Image-89161-192

Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

Catalog Number: (89161-192)
Supplier: Enzo Life Sciences
Description: MMP substrate
Image Unavailable-M-1895.0005BA

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ Trifluoroacetate

Supplier: Bachem Americas
Description: Mca-PLGL-Dpa-AR-amide is a very sensitive FRET substrate for continuous assays and in situ determination of the matrix metalloproteinase activity. Cleavage at the Gly-Leu bond separates the highly fluorescent Mca group from the efficient 2,4-dinitrophenyl quencher, resulting in an increase in fluorescence intensity. The kcat/Km values for the punctuated metalloproteinase (MMP-7) and for gelatinase (MMP-2), e.g., are 1.7·10⁵ and 6.3·10⁵ M⁻¹s⁻¹, respectively.

Product Image-89156-472

Matrix Metalloproteinase-9 (MMP-9) Fluorometric Drug Discovery Kit, Enzo Life Sciences

Catalog Number: (89156-472)
Supplier: Enzo Life Sciences
Description: A QuantiZymeTM Assay SystemThe MMP-9 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-9 (MMP-9, gelatinase B) using a quenched fluorogenic peptide: OmniMMPTM fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH
Image Unavailable-M-2405.0005BA

Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin Trifluoroacetate

Supplier: Bachem Americas
Description: Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.

Image Unavailable-I-1105.0250BA

Boc-LGR-MCA

Supplier: Bachem Americas
Description: Sequence: Boc-Leu-Gly-Arg-AMC

Image Unavailable-102996-764

390 MMP FRET Substrate II, Mca-DNP

Catalog Number: (102996-764)
Supplier: Anaspec Inc
Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a generic fluorogenic substrate for assaying MMPs. Abs/Em = 325/393 nm.
Sequence:Mca-PLGL-Dap(Dnp)-AR
MW:1094.2 Da
% peak area by HPLC:95
Storage condition:-20° C
Image Unavailable-102996-760

390 MMP FRET Substrate I, Mca-DNP

Supplier: Anaspec Inc
Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a fluorogenic substrate that is best cleaved by MMP-7, 8, 9 and 13. The highly fluorescent Mca moiety is efficiently quenched by energy transfer to the Dnp group. The punctuated metallo proteinase (PUMP, EC 3.4.24.23) cleaves the substrate at the Gly-Leu bond with a 190-fold increase in fluorescence (Abs/Em = 325/393 nm). In human MMP assays, this substrate is about 50 to 100 times more sensitive than the generic MMP substrate, Dnp-PLGLWAr-NH2.
Sequence:Mca-PLGL-Dap(Dnp)-AR-NH2
MW:1093.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Image Unavailable-M-2110.0001BA

NFF 3

Supplier: Bachem Americas
Description: Sequence: Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH₂
Synonym(s): NFF-3

Image Unavailable-M-2255.0001BA

Human Mca-(endo-1a-Dap(Dnp))-TNF-alpha (-5 to +6) amide Trifluoroacetate

Supplier: Bachem Americas
Description: ADAM-17 endopeptidase is also called TACE or TNFα-converting enzyme.

Image Unavailable-M-2270.0005BA

Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)-OH

Supplier: Bachem Americas
Description: See also M-2460 and M-2465.

Image Unavailable-M-2105.0005BA

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ Trifluoroacetate

Supplier: Bachem Americas
Description: The FRET substrate Mca-RPKPYA-Nva-WMK(Dnp)-amide was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M⁻¹s⁻¹) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M⁻¹s⁻¹), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested this fluorogenic substrate with a kcat/Km of 243000 M⁻¹s⁻¹. For a fluorescent standard see M-2250.

Image Unavailable-M-2670.0005BA

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH₂ Trifluoroacetate

Supplier: Bachem Americas
Description: Highly selective MMP-12 FRET substrate with a kcat/Km value of 1.85 · 10⁵ M⁻¹s⁻¹. Poor substrate of other MMPs with the exception of MMP-13 (kcat/Km = 0.53 · 10 ⁵ M⁻¹s⁻¹) and MMP-9 (0.33 · 10⁵ M⁻¹s⁻¹).

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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