You Searched For: Reciprocating+Shakers

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Accessories for MaxQ™ 7000 Benchtop Water Bath Shakers, Thermo Scientific

Supplier: Thermo Fisher Scientific

Description: For use with MaxQ* 7000 benchtop water bath shakers. Allows for under lab bench operation of shaker.

Mini-100 Orbital Genie™ Orbital Shakers, 230 V

Supplier: Scientific Industries

Description: Low profile, compact footprint, variable speed Orbital shaker with non-slip platform, chemical resistant, with spill-proof edges.

Mini Tube Rotator, PTR-25, 360°, Grant Instruments

Catalog Number: (89402-918)

Supplier: GRANT USA INC.

Description: Compact rotator with easy to use controls, provides thorough end over end mixing of samples in tubes up to 50 ml

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Orbital Shaker, CO₂ Resistant

Catalog Number: (77507-388)

Supplier: NEST SCIENTIFIC

Description: This product is developed for it to be used in high humidity and CO₂ environment. Also, it can be used as a common shaker. Its driven mechanism is composed of magnets and sealed electrical coils. It is maintenance free and has long life time.

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Anti-JAK2 Rabbit Polyclonal Antibody

Catalog Number: (77439-788)

Supplier: Bioss

Description: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.