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Product Image-76628-472

VWR® 401 L CO₂ Incubator Shakers

Supplier: VWR International
Description: The innovative and versatile VWR® 401 L CO₂ Incubator Shakers features CO₂, shaking, temperature and humidity controls, with color touchscreen. These units have a stackable design to minimize footprint, and optional Wi-Fi monitoring, making them an excellent choice for many applications.

Product Image-76549-930

VWR® Multitube Vortex Mixer

Catalog Number: (76549-930)
Supplier: VWR International
Description: The VWR® multitube vortex mixer allows hands-free, high capacity vortexing.
Product Image-10752-230

Anti-KIAA0226 Rabbit Polyclonal Antibody

Catalog Number: (10752-230)
Supplier: Prosci
Description: Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.
Product Image-10069-790

Anti-LDLR Chicken Polyclonal Antibody

Catalog Number: (10069-790)
Supplier: Prosci
Description: Low density lipoprotein receptor. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Product Image-97043-562

VWR® Standard Heavy-Duty Vortex Mixer

Catalog Number: (97043-562)
Supplier: VWR International
Description: Variable speed analog mixer features a heavy-duty design and efficient motor that permits continuous duty operation and the ability to handle accessory components over the entire speed range.

Certificates Environmentally Preferable CSA Certified Product available on GSA Advantage®


Product Image-10061-806

Anti-PDGFB Rabbit Polyclonal Antibody

Catalog Number: (10061-806)
Supplier: Prosci
Description: PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB). Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.
Product Image-11010-506

Biodissolution Reciprocating Cylinder Accessories, Apparatus 3, Quality Lab Accessories

Supplier: QLA
Description: QLA manufactures Biodissolution Accessories and Glassware for Agilent/VanKel BIO-DIS testers.

Product Image-10356-822

Anti-ANGPT1 Rabbit Polyclonal Antibody

Catalog Number: (10356-822)
Supplier: Bioss
Description: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010].
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VWR® Transfer Caps for Shaker Flasks

Supplier: VWR International
Description: These transfer caps are for the VWR® 5 L shaker flasks. Many caps are available for various applications.

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Product Image-89161-568

MG-132

Supplier: Enzo Life Sciences
Description: MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

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Product Image-89351-282

Anti-LDLR Mouse Monoclonal Antibody [clone: 15C8]

Catalog Number: (89351-282)
Supplier: Genetex
Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Product Image-14231-844

Accessories for VWR Signature™ Benchtop Shaking Incubators

Supplier: VWR International

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Product Image-76549-928

VWR® Vortex Mixer

Catalog Number: (76549-928)
Supplier: VWR International
Description: VWR® variable speed vortex mixer with standard cup head.
Product Image-470230-486

Ward's® Mini Vortexer

Catalog Number: (470230-486)
Supplier: VWR International
Description: Powerful, Mini Vortex Mixer.
Product Image-89146-820

MG-115

Catalog Number: (89146-820)
Supplier: Enzo Life Sciences
Description: Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.
Product Image-14005-832

VWR® Advanced Multi-Tube Vortexer, 230 V (Export Only)

Catalog Number: (14005-832)
Supplier: VWR International
Description: Advanced multi-tube vortexer features touchpad controls with independent LED displays for speed and time.

UL Listed CE Compliant Irregular Voltage Product available on GSA Advantage®


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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