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Anti-MUC1 Mouse Monoclonal Antibody (CF647) [clone: MUC1/955]

Supplier: Biotium
Description: This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Image Unavailable-76108-966

Anti-CTDSPL Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76108-966)
Supplier: Bioss
Description: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Image Unavailable-76081-234

Anti-HSP58 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76081-234)
Supplier: Bioss
Description: This gene encodes a member of the "fused gene" family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Image Unavailable-10404-204

Anti-PILRB1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10404-204)
Supplier: Bioss
Description: Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing.
Image Unavailable-10405-520

Anti-PILRB1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10405-520)
Supplier: Bioss
Description: Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing.
Image Unavailable-102147-910

OIF Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-13918)

Catalog Number: (102147-910)
Supplier: Novus Biologicals
Description: OIF Overexpression Lysate (Adult Normal)
Image Unavailable-102147-908

OIF Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-13917)

Catalog Number: (102147-908)
Supplier: Novus Biologicals
Description: OIF Overexpression Lysate (Adult Normal)
Image Unavailable-10404-208

Anti-PILRB1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10404-208)
Supplier: Bioss
Description: Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing.
Image Unavailable-10424-640

Anti-CRNN Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10424-640)
Supplier: Bioss
Description: This gene encodes a member of the "fused gene" family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Image Unavailable-10424-642

Anti-CRNN Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10424-642)
Supplier: Bioss
Description: This gene encodes a member of the "fused gene" family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Image Unavailable-76084-304

Anti-CTDSPL Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76084-304)
Supplier: Bioss
Description: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Image Unavailable-10405-524

Anti-PILRB1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10405-524)
Supplier: Bioss
Description: Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing.
Image Unavailable-10424-636

Anti-CRNN Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10424-636)
Supplier: Bioss
Description: This gene encodes a member of the "fused gene" family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Image Unavailable-10424-638

Anti-CRNN Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10424-638)
Supplier: Bioss
Description: This gene encodes a member of the "fused gene" family of proteins, which contain N terminus EF hand domains and multiple tandem peptide repeats. The encoded protein contains two EF hand Ca2+ binding domains in its N terminus and two glutamine and threonine rich 60 amino acid repeats in its C terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.
Product Image-10204-980

Handheld Fluorimeter, ANDalyze

Catalog Number: (10204-980)
Supplier: ANDalyze Inc
Description: The AND1100 Fluorimeter tests for metals in water in two steps and less than two minutes, significantly reducing the test expenditures, complexity and wait times experienced in traditional tests. Powered by DNA, it is a breakthrough in streamlining the water analysis and reporting processes. The AND1100 Fluorimeter is a platform centric portable device for heavy metals testing for drinking water and industrial water supplies. It uses an extremely sensitive measurement technique in tandem with ANDalyze sensor kits to determine the toxicity levels of heavy metal contamination. Sensor kits are available for lead, uranium, copper, mercury, zinc, and cadmium; with more to come.
Image Unavailable-10365-906

Anti-GAL3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10365-906)
Supplier: Bioss
Description: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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