You Searched For: PD-173955

Supplier: BeanTown Chemical

Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02

SDS

Supplier: Strem Chemicals Inc

Description: CAS #: 14852-83-6. Size: 5g.

Supplier: ACROBIOSYSTEMS INC MS

Description: PD-L1/B7-H1 Protein, Host: HEK293, Species Reactivity: Cynomolgus, Purity: >95% by SDS-PAGE, Molecular Characterization: fused with a polyhistidine tag at the C-terminus, calculated MW of 27.1 kDa, Synonym: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1, Storage: 4 deg C, Size: 1mg

Catalog Number: (75791-904)

Supplier: Prosci

Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Catalog Number: (75791-760)

Supplier: Prosci

Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Supplier: BeanTown Chemical

Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02

SDS

Catalog Number: (76634-556)

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Catalog Number: (75843-274)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Catalog Number: (76163-662)

Supplier: Prosci

Description: PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

Catalog Number: (76163-660)

Supplier: Prosci

Description: PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

Supplier: Thermo Scientific Chemicals

Description: Tetrakis(triphenylphosphine)palladium(0) 99%

Catalog Number: (AA46383-03)

Supplier: Thermo Scientific Chemicals

Description: Dichloro[1,1'-bis(dicyclohexylphosphino)ferrocene]palladium(II), Pd 14.1%

SDS Certificates

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00011373

SDS Certificates

Supplier: Abcam

Description: Rat monoclonal [CAL10] to PD-L1 - Rat IgG2a.

New Product

Supplier: BeanTown Chemical

Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02

SDS

Catalog Number: (76198-900)

Supplier: Genscript

Description: The product is specific for human PD-L1 (UniProt Accession: Q9NZQZ). This antibody blocks human PD-1 binding with human PD-L1 expression cell line in flow cytometry assay.