You Searched For: PD-173955

Catalog Number: (10797-768)

Supplier: Prosci

Description: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-?. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-? by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-? secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

Catalog Number: (102164-668)

Supplier: Novus Biologicals

Description: The PD-ECGF / Thymidine Phosphorylase Antibody from Novus Biologicals is a rabbit polyclonal antibody to PD-ECGF / Thymidine Phosphorylase. This antibody reacts with human. The PD-ECGF / Thymidine Phosphorylase Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

Catalog Number: (103294-276)

Supplier: Novus Biologicals

Description: The VISTA / B7-H5 / PD-1H Antibody (855328) [DyLight 755] from Novus Biologicals is a mouse monoclonal antibody to VISTA / B7-H5 / PD-1H. This antibody reacts with human. The VISTA / B7-H5 / PD-1H Antibody (855328) [DyLight 755] has been validated for the following applications: Flow Cytometry.

Supplier: ACROBIOSYSTEMS INC MS

Description: Canine PD-L1/B7-H1 Protein, Fc Tag, Source: expressed from human 293 cells (HEK293). It contains AA Phe 19 - His 238, Predicted N-terminus: Phe 19, protein carries a human IgG1 Fc tag at the C-terminus, Synonyms: PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1, Size: 100uG

Supplier: Abcam

Description: Rabbit monoclonal [28-8] to PD-L1.

New Product

Catalog Number: (76163-630)

Supplier: Prosci

Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

Catalog Number: (101419-084)

Supplier: Strem Chemicals Inc

Description: Escat

Supplier: Abcam

Description: Rabbit monoclonal [CAL10] to PD-L1.

New Product

Supplier: Strem Chemicals Inc

Description: CAS #: 7440-05-3. Size: 50g.

Catalog Number: (AA10535-03)

Supplier: Thermo Scientific Chemicals

Description: Pd 31.1%,Crystalline,WARNING: Irritates skin and eyes,1g.

SDS Certificates

Supplier: Ambeed

Description: Methanesulfonato{(R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-t-butylphosphine}(2'-amino-1,1'-biphenyl-2-yl)palladium(II) 98%

New Product

Supplier: Thermo Scientific Chemicals

Description: Palladium 5% on calcium carbonate lead poisoned (3.5% Pb)

Supplier: ACROBIOSYSTEMS INC MS

Description: Human Recombinant PD-1 (from HEK293)

Supplier: ACROBIOSYSTEMS INC MS

Description: Biotinylated Human PD-L1 / B7-H1 (19-134) Protein, His,Avitag™ (recommended for biopanning), ACROBiosystems

Catalog Number: (75794-280)

Supplier: Prosci

Description: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

Supplier: Thermo Scientific Chemicals

Description: Slightly soluble in water. Soluble in NH3OH. Insoluble in chloroform, acetone

SDS Certificates