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Supplier: Chem Impex International
Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: Used in nutrient, gelling agent, salt substitute and yeast food.

New Product

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: 5(6)-Carboxyfluorescein N-hydroxysuccinimide ester (5/6-FAM SE)

New Product

Supplier: Chem Impex International
Description: Excellent support for the synthesis of portected peptides using Boc strategy. Cleavage can effected by various nucleophiles.

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: 1-Hydroxybenzotriazole hydrate ≥99% (by HPLC) wetted with ca. 20% water, Powder

New Product

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: tert-Butylchlorodiphenylsilane ≥98% (by GC)

New Product

Supplier: Chem Impex International
Supplier: Chem Impex International

Supplier: Chem Impex International
Supplier: Chem Impex International
Supplier: Chem Impex International

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction.

New Product

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: Acridine yellow G ≥90% (dye basis) CI 46025

New Product

Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: 4-Methylumbelliferyl-β-D-xylopyranoside ≥98% (by HPLC)

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Supplier: CHEM-IMPEX INTERNATIONAL, INC
Description: Cefsulodin sodium salt hydrate ≥98% (by HPLC) USP

New Product

Catalog Number: (10072-802)
Supplier: Prosci
Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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