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Product Image-RL610-4512

Anti-IgG gamma RabbitPolyclonal Antibody (AP (Alkaline Phosphatase))

Catalog Number: (RL610-4512)
Supplier: Rockland Immunochemical
Description: Anti-Mouse IgG (gamma chain) Antibody is suitable for use in immunoelectrophoresis, western-blot, competitive western-blot, ELISA and competitive ELISA assays. Specific conditions for reactivity and signal detection should be optimized by the end user.
Product Image-10802-276

Anti-CASP5 Rabbit Polyclonal Antibody

Catalog Number: (10802-276)
Supplier: Rockland Immunochemical
Description: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.
Image Unavailable-BT138375-250G

1,3-Propanesultone ≥99%

Supplier: BeanTown Chemical
Description: CAS: 1120-71-4; EC No: 214-317-9; MDL No: MFCD00005355; RTECS: RP5425000 UN No: UN2811; Haz Class: 6.1; Packing Group: III Solid; Molecular Formula: C3H6O3S; MW: 122.14 Melting Point: 30-33°; Boiling Point: 180°/30 mmHg; Flash point: 110°C (230°F) Density (g/mL): 1.392 Moisture Sensitive

SDS

Image Unavailable-RL610-4042

Anti-IgG2b gamma Rabbit Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))

Catalog Number: (RL610-4042)
Supplier: Rockland Immunochemical
Description: Secondary Rabbit Anti-IgG2b Reacts with Mouse
Image Unavailable-10357-814

Anti-MLH1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10357-814)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
Image Unavailable-76194-458

Anti-JUP Mouse Monoclonal Antibody [clone: CTNG/1664]

Catalog Number: (76194-458)
Supplier: Prosci
Description: Plakoglobin, also known as junction plakoglobin or gamma Catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Gamma Catenin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.<p>Gamma Catenin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Gamma Catenin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki]
Product Image-RL610-4343

Anti-IgG3 gamma Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (RL610-4343)
Supplier: Rockland Immunochemical
Description: Mouse IgG3 heavy chain antibody is suitable for immunoblotting (western or dot blot), ELISA, and immunochemistry requiring extremely low background levels, lot-to-lot consistency, high titer and specificity.
Image Unavailable-10772-398

Human Recombinant Vimentin (from E. coli)

Supplier: Peprotech
Description: Vimentin is a class III intermediate filament protein predominantly found in cells of mesenchymal origins, such as vascular endothelium and blood cells, where it functions as a major cytoskeletal component. Due to its importance and abundance in the cytoskeletal structure of mesenchymally-derived cells, vimentin is frequently used as a developmental marker within cells of mesenchymal origin or cells undergoing epithelial-mesenchymal transition, which can occur during both normal and metastatic growth. An active participant within several critical processes of cellular organization and protein regulation, vimentin is involved in the anchorage of organelles within the cytoplasmic matrix, development of astrocytes, and the disassembly of cellular components during the execution phase of apoptosis. Abnormalities in the normal physiological pathways of vimentin have been implicated in deficient motility and directional migration involved in wound healing, cellular growth and development, as well as the adhesion-site accumulation of vimentin on lens epithelial cells in cases of dominant cataracts. Recombinant Human Vimentin is a 54.3 kDa protein consisting of 471 amino acid residues, including a 6-residue C-terminal His-Tag.

Image Unavailable-102862-158

Human Recombinant Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A

Supplier: Bon Opus Biosciences
Description: Bon Opus Biosciences offers quality recombinant proteins products covering a broad collection of cytokines, enzymes, diagnostic and detection reagents, and other protein-related products

Product Image-RL610-4612

Anti-IgG gamma RabbitPolyclonal Antibody (Biotin)

Catalog Number: (RL610-4612)
Supplier: Rockland Immunochemical
Description: This product has been assayed against 1.0 µg of Mouse IgG in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Product Image-10104-744

Anti-CEBPB Rabbit Polyclonal Antibody

Catalog Number: (10104-744)
Supplier: Prosci
Description: The protein encoded by this intronless gene, CEBPB, is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
Product Image-76068-866

Anti-Camk1g Rabbit Polyclonal Antibody

Catalog Number: (76068-866)
Supplier: Prosci
Description: For WB starting dilution is: 1:1000
Image Unavailable-10072-862

Human Recombinant IFN gamma (from E. coli)

Catalog Number: (10072-862)
Supplier: Prosci
Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7 kDa protein containing 143 amino acid residues.
Image Unavailable-10243-688

Anti-C4b-A Rabbit Polyclonal Antibody

Catalog Number: (10243-688)
Supplier: Bioss
Description: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Image Unavailable-RL609-1612

Anti-IgG gamma Goat Polyclonal Antibody (Biotin)

Catalog Number: (RL609-1612)
Supplier: Rockland Immunochemical
Description: This product has been assayed against 1.0 µg of Human IgG in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Image Unavailable-77439-518

Anti-PLK4/STK18 Rabbit Polyclonal Antibody

Catalog Number: (77439-518)
Supplier: Bioss
Description: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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