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Image Unavailable-RL610-4112

Anti-IgG gamma RabbitPolyclonal Antibody

Catalog Number: (RL610-4112)
Supplier: Rockland Immunochemical
Description: Secondary Rabbit Anti-IgG (gamma chain) Reacts with Mouse
Image Unavailable-10244-084

Anti-Complement C4 gamma chain Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10244-084)
Supplier: Bioss
Description: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Image Unavailable-10341-078

Anti-CD163 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10341-078)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Image Unavailable-76082-324

Anti-CD163/M130 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76082-324)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Image Unavailable-10341-074

Anti-CD163 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10341-074)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Image Unavailable-RL609-1212

Anti-IgG gamma Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (RL609-1212)
Supplier: Rockland Immunochemical
Description: Secondary Goat Anti-IgG (gamma chain) Reacts with Human
Image Unavailable-RL609-1312

Anti-IgG gamma Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (RL609-1312)
Supplier: Rockland Immunochemical
Description: Secondary Goat Anti-IgG (gamma chain) Reacts with Human
Image Unavailable-RL609-4912

Anti-IgG gamma Rabbit Polyclonal Antibody (Texas Red®)

Catalog Number: (RL609-4912)
Supplier: Rockland Immunochemical
Description: Secondary Rabbit Anti-IgG (gamma chain) Reacts with Human
Image Unavailable-10244-086

Anti-Complement C4 gamma chain Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10244-086)
Supplier: Bioss
Description: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Image Unavailable-10244-090

Anti-Complement C4 gamma chain Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10244-090)
Supplier: Bioss
Description: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Product Image-RL609-4012

Anti-IgG gamma Rabbit Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))

Catalog Number: (RL609-4012)
Supplier: Rockland Immunochemical
Description: Secondary Rabbit Anti-IgG (gamma chain) Reacts with Human
Image Unavailable-99990-044

Anti-IgG Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (99990-044)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with the gamma chain of human IgG. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.
Image Unavailable-RL609-4212

Anti-IgG gamma Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (RL609-4212)
Supplier: Rockland Immunochemical
Description: Secondary Rabbit Anti-IgG (gamma chain) Reacts with Human
Image Unavailable-10341-082

Anti-CD163 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10341-082)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Image Unavailable-102992-160

Baricitinib phosphate salt ≥95%

Supplier: Adipogen
Description: Baricitinib is a selective JAK1 and JAK2 inhibitor. IC(50) values are 5.9nm for JAK1, and 5.7nM for JAK2. In cell based assays Baricitinib/INCB-28050 demonstrated inhibition of intracellular signaling of multiple pro-inflammatory cytokines including IL-6 and IL-23 at concentrations of <lt/> 50nM, and also showed good efficacy in a number of animal models at doses of 10mg/kg and below. Baricitinib is in Phase III development as a potential treatment for rheumatoid arthritis. It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy

Image Unavailable-75842-960

Anti-CD16 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: CB16]

Catalog Number: (75842-960)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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