You Searched For: H-D-Ala-Leu-Lys-AMC

Supplier: Bachem Americas

Description: Sequence: H-Gln-AMC

Catalog Number: (I-1475.0050BA)

Supplier: Bachem Americas

Description: Sequence: H-Ser-Tyr-AMC

Supplier: Bachem Americas

Description: Sequence: Z-Gly-Pro-AMC

Supplier: Bachem Americas

Description: Sequence: Ac-Met-AMC

Catalog Number: (76482-160)

Supplier: AAT BIOQUEST INC

Description: Z-Gly-Pro-AMC is a fluorogenic substrate for the determination of post-proline cleaving enzyme (prolyl endopeptidase).

Supplier: Bachem Americas

Description: Sequence: H-Asp-AMC

Supplier: Bachem Americas

Description: Sequence: H-Phe-AMC

Supplier: Bachem Americas

Description: Sequence: Z-Val-Val-Arg-AMC

Catalog Number: (76482-126)

Supplier: AAT BIOQUEST INC

Description: Pro-AMC is a sensitive fluorogenic protease substrate.

Supplier: Anaspec Inc

Description: Somatostatin [SST, GHIH (growth hormone-inhibiting hormone) or SRIF (somatotropin release-inhibiting factor)] is a cyclic peptide hormone existing as two isoforms and produced in the pancreas islet, GI tract and the central nervous system. Tetradecapeptide Somatostatin-14 (SRIF-14, the originally identified somatostatin) and the 28-amino acid Somatostatin-28 (SRIF-28) have similar biological activities but differ in their potency. Somatostatins regulate the endocrine system: they inhibit the release of growth hormone in contrast to Growth Hormone Factor (GRF), which stimulates the release of growth hormone. They also inhibit the release of prolactin and thyrotropin, peptide hormones from the pituitary gland and glucagon and insulin from the pancreas. They control the secretion of gut hormones and function as neurotransmitters.
Sequence: AGCKNFFWKTFTSC (Disulfide bridge: 3-14)
MW: 1637.9 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Bachem Americas

Description: Sequence: H-Arg-AMC

Supplier: Bachem Americas

Description: Sequence: H-Gly-Arg-AMC

Catalog Number: (89160-982)

Supplier: Enzo Life Sciences

Description: Substrate for cathepsin H and aminopeptidases

Supplier: Bachem Americas

Description: Sequence: H-Orn-AMC

Catalog Number: (95043-776)

Supplier: Enzo Life Sciences

Description: Glucose-regulated protein 94 (Grp94, gp96), an abundant resident endoplasmic reticulum (ER) lumenal stress protein, belongs to the Hsp90 family of molecular chaperones along with cytosolic Hsp90. Grp94 and such other resident soluble proteins of the ER as the Ca 2+ binding protein subfamily (CaBP, CaBPI, CaBP2 and calreticulin) possess the C-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL), a sorting signal considered responsible for the retention of these proteins in the pre-Golgi compartments. Stress conditions such as glucose starvation and heat shock which promote protein misfolding or unfolding increase Grp94 expression. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Grp94 and Hsp90 share high sequence identity and apparently identical adenosine nucleotide dependent modes of regulation, although previous data suggests that Hsp90 and Grp94 may differ in their nucleotide binding properties. The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket which also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol. However, the molecular basis for adenosine nucleotide-dependent regulation of Grp94 remains unclear. Data supports a ligand dependent regulation of Grp94 function, and suggests a model whereby Grp94 function is regulated through a ligand -dependent conversion of Grp94 from an inactive to an active conformation.

Supplier: Bachem Americas

Description: Sequence: H-Ser-AMC