You Searched For: GNF-5837


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Supplier: Adipogen
Description: Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC(50) = 42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC(50) = 1 and 0.5µM) and Ba/F3-Tel-KDR and wt-Ba/F3 cells (IC(50) = 3.0 and 5.6µM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.).

Supplier: Ambeed
Description: 1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea, Purity: 98+%, CAS Number: 1033769-28-6, Appearance: Pale-yellow to Yellow-brown to Orange Solid, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 10mg

Catalog Number: (TS468191000)
Supplier: Thermo Scientific Chemicals
Description: Chemical probes can be used to help establish the relationship between a molecular target and the broader biological consequences of modulating that target in cells or organisms.

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Catalog Number: (103468-426)
Supplier: Affymetrix, Inc.
Description: MA1-5837 detects Mus81 in human samples. MA1-5837 has been successfully used in Western blot and immunoprecipitation procedures. The MA1-5837 immunogen is human Mus81. Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

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Supplier: Ambeed
Description: GNF-5 98%

Supplier: Ambeed
Description: 8-Nitrotryptanthrin, Purity: 98%, CAS Number: 77603-42-0, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 1mg

Catalog Number: (TCF0351-100MG)
Supplier: TCI America
Description: CAS Number: 5837-72-9
MDL Number: MFCD00191651
Molecular Formula: C5H6O3
Molecular Weight: 114.10
Purity/Analysis Method: >95.0% (GC)
Form: Crystal
Boiling point (°C): 88
Melting point (°C): 40
Storage Temperature: 0-10°C

Supplier: Ambeed
Description: N-(5-(4-Acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-fluoro-3-methyl-[2,4'-bipyridin]-5-yl)acetamide, Purity: 98+%, CAS Number: 1243245-18-2, Appearance: Solid, Storage: Inert atmosphere, Store in freezer, under -20 C, Size: 5mg

Supplier: Thermo Scientific Chemicals
Description: 98% 25G
Supplier: Ace Glass
Description: This Luer Bottom Drip Adapter, with or without flow regulator valve, is used with Ace-Thred columns.

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Catalog Number: (103964-500)
Supplier: ASTATECH INC MS
Description: GNF 5837 0.1G

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Catalog Number: (102875-792)
Supplier: R&D Systems
Description: GNF 5837 (10 MG)


Catalog Number: (102875-794)
Supplier: R&D Systems
Description: GNF 5837 (50 MG)


Catalog Number: (220180-493)
Supplier: Sigma Aldrich
Description: GNF-2

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Catalog Number: (103956-994)
Supplier: ASTATECH INC MS
Description: GNF-2 0.5G

Blocked

Catalog Number: (103956-992)
Supplier: ASTATECH INC MS
Description: GNF-2 0.1G

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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