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Image Unavailable-10456-316

Anti-ORM1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10456-316)
Supplier: Bioss
Description: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Image Unavailable-10407-570

Anti-CYP4A11/22 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10407-570)
Supplier: Bioss
Description: Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.
Image Unavailable-77440-324

Anti-PKC iota Rabbit Polyclonal Antibody

Catalog Number: (77440-324)
Supplier: Bioss
Description: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Product Image-10108-794

Anti-CYP4F11 Rabbit Polyclonal Antibody

Catalog Number: (10108-794)
Supplier: Prosci
Description: CYP4F11 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The specific function of this protein has not been determined.This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The specific function of this protein has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away.
Image Unavailable-103007-820

(Arg)9,Biotin

Catalog Number: (103007-820)
Supplier: Anaspec Inc
Description: (Arg)9 is a cell-permeable peptide used for drug delivery.It can traverse the plasma membrane of eukaryotic cells. This peptide sequence with nine arginines contains a biotin group attached to the epsilon amino group of lysine at the N-terminus.
Sequence:Biotin-LC-RRRRRRRRR-NH2
MW:1762.2 Da
% peak area by HPLC:95
Storage condition:-20° C
Product Image-10108-932

Anti-UGT1A1 Rabbit Polyclonal Antibody

Catalog Number: (10108-932)
Supplier: Prosci
Description: UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Product Image-10101-204

Anti-KCNQ2 Rabbit Polyclonal Antibody

Catalog Number: (10101-204)
Supplier: Prosci
Description: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Product Image-16171-669

Straight Plug Rubber Stoppers, Wheaton

Catalog Number: (16171-669)
Supplier: DWK Life Sciences (KIMBLE)
Description: Wheaton straight plug stoppers provide maximum sealing for vials with a straight-wall glass finish

Certificates Small Business Enterprise


Image Unavailable-76633-554

Anti-Heat Shock Protein 70 Mouse Monoclonal Antibody [clone: W27]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to constitutive (HSP73) and inducible (HSP72) form of HSP70. HSP70 is found to be associated with steroid receptors, actin, P53, polyoma T antigen, nucleotides and other known proteins. HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs and other damaging conditions.

Image Unavailable-10407-576

Anti-CYP4A11/22 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10407-576)
Supplier: Bioss
Description: Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.
Image Unavailable-103301-796

Pump 11 Elite Syringe Pumps, Harvard Apparatus

Catalog Number: (103301-796)
Supplier: Harvard Apparatus
Description: The Pump 11 Elite is an accurate, low flow syringe pumps designed for use in applications including mass spec calibration, drug and nutritional studies, reactor dosing, and electro-spinning
Image Unavailable-IC15153983

Lecithin (from soy bean) ≥90%, waxy orange-yellow chunky solid, Water Dispersable Grade

Supplier: MP Biomedicals
Description: Lecithin is used as an emulsifier and solubilizer for drugs in an aqueous solution, also as a vehicle for liposomes.

SDS Certificates

Product Image-76333-062

Portable/Deployable Ultra-Low Temperature Freezer, Model ULT25NEU, Stirling Ultracold, Global Cooling

Catalog Number: (76333-062)
Supplier: Stirling Ultracold
Description: The ULT25NEU is the only portable ULT freezer solution available today for bringing ULT storage to the patient. This small, lightweight, and efficient portable -80 °C freezer is ideal for clinical trials and biologic drug delivery.

Environmentally Preferable


Image Unavailable-77680-324

BioReady Gold Nanoshells, 150 nm for Passive Conjugation

Supplier: NANOCOMPOSIX, INC.
Description: 150 nm gold nanoshells for passive adsorption combine strong plasmonic optical properties with surface chemistry designed for passive conjugation. These nanoparticles are used in applications such as immunodiagnostics, lateral flow assays, nanomedicine, drug delivery, biosensors, and more.

New Product

Product Image-89160-680

Kavain (+/-) ≥98%

Supplier: Enzo Life Sciences
Description: Kavain is one constituent of kava-kava, an herbal drug of the South Pacific islands, which displays anti-convulsive, anxiolytic, analgesic and muscle relaxing properties. Kavain inhibits voltage-dependent Na+ channels in rat CA1 hippocampal neurons. It displays protective effects in the MPTP mouse model of Parkinson's disease but potentiates NMDA toxicity in the developing hippocampus.

Image Unavailable-76120-360

Anti-Digoxin Mouse Monoclonal Antibody [clone: 2E2] (ALEXA FLUOR® 750)

Catalog Number: (76120-360)
Supplier: Bioss
Description: Digoxin is a beta blocker drug originally derived from the foxglove plant, <i>Digitalis lanata</i>. Digoxin is used primarily to improve the pumping ability of the heart in congestive heart failure (CHF), and treat problems such as high blood pressure. It is also used to help normalize some dysrhythmias (abnormal types of heartbeat).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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