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Catalog Number: (103271-538)
Supplier: Novus Biologicals
Description: The TCP1-delta Antibody from Novus Biologicals is a rabbit polyclonal antibody to TCP1-delta. This antibody reacts with human, mouse, rat. The TCP1-delta Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (103271-540)
Supplier: Novus Biologicals
Description: The TCP1-beta Antibody from Novus Biologicals is a rabbit polyclonal antibody to TCP1-beta. This antibody reacts with human, mouse, rat. The TCP1-beta Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (102981-404)
Supplier: Adipogen
Description: In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation. The optimal inhibitory DNA motif consists of a pyrimidine-rich triplet, preferably CCT, which is positioned 5- to the GGG sequence in a singlestranded DNA molecule. Additionally, both the optimal spacing between the CCT and GGG motifs, as well as their relative order to each other, is of crucial importance for the inhibitory DNA action. Interestingly, although both TLR7/TLR8 ligands and bacterial DNA share the endosomal compartment for receptor binding and signal transduction, certain iODNs (G-type) suppress only TLR9-mediated activation, whereas prototype class I iODN may also interfere with the activation via the TLR7/TLR8 pathway. Recently, intriguing evidence has been presented that for some iODN classes the immuno-modulatory biological activity shows only limited sequence dependency or may not even involve TLR-mediated uptake and signaling pathways. For example iODNs of the class II are thought to act on immune activation through inhibition of STAT signaling and independent of TLR signaling via binding to a yet to be identified 'ODN-receptor'. Slightly modified phosphodiester versions of the most potent inhibitory ODNs were also able to profoundly block the immune activation of macrophages and just recently prove to be valuable tools for in vivo use in experimental animal models of inflammatory and auto-immune diseases. Based upon these recent insights the following classification for iODNs has been suggested: Class I: G-stretch ODNs: TLR9-specific competitors, some iODNs may also affect TLR7 and TLR8 signalingClass II: ODNs with telomeric repeats: TLR-independent inhibitors of STAT signaling (cellular uptake via an 'ODN receptor'?)Class III: Inhibitors of DNA uptake in a sequence independent mannerClass IV: Long phosphorothioate ODNs as direct competitors of TLR9 signaling in a sequence independent manner


Supplier: Adipogen
Description: In recent years several groups have studied the sequence requirements, specificity, signalling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation. The optimal inhibitory DNA motif consists of a pyrimidine-rich triplet, preferably CCT, which is positioned 5- to the GGG sequence in a singlestranded DNA molecule. Additionally, both the optimal spacing between the CCT and GGG motifs, as well as their relative order to each other, is of crucial importance for the inhibitory DNA action. Interestingly, although both TLR7/TLR8 ligands and bacterial DNA share the endosomal compartment for receptor binding and signal transduction, certain iODNs (G-type) suppress only TLR9-mediated activation, whereas prototype class I iODN may also interfere with the activation via the TLR7/TLR8 pathway. Recently, intriguing evidence has been presented that for some iODN classes the immuno-modulatory biological activity shows only limited sequence dependency or may not even involve TLR-mediated uptake and signaling pathways. For example iODNs of the class II are thought to act on immune activation through inhibition of STAT signaling and independent of TLR signaling via binding to a yet to be identified 'ODN-receptor'. Slightly modified phosphodiester versions of the most potent inhibitory ODNs were also able to profoundly block the immune activation of macrophages and just recently prove to be valuable tools for in vivo use in experimental animal models of inflammatory and auto-immune diseases. Based upon these recent insights the following classification for iODNs has been suggested: Class I: G-stretch ODNs: TLR9-specific competitors, some iODNs may also affect TLR7 and TLR8 signalingClass II: ODNs with telomeric repeats: TLR-independent inhibitors of STAT signalling (cellular uptake via an 'ODN receptor'?)Class III: Inhibitors of DNA uptake in a sequence independent mannerClass IV: Long phosphorothioate ODNs as direct competitors of TLR9 signaling in a sequence independent manner

Catalog Number: (103271-536)
Supplier: Novus Biologicals
Description: The TCP1-eta Antibody from Novus Biologicals is a rabbit polyclonal antibody to TCP1-eta. This antibody reacts with human, mouse, rat. The TCP1-eta Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (102870-978)
Supplier: R&D Systems
Description: CCT 018159 (50 MG)


Catalog Number: (MSPP-CCT123010)
Supplier: Vector Laboratories
Description: SULFO DBCO MALEIMIDE CCT-1230

New Product


Catalog Number: (MSPP-CCT140625)
Supplier: Vector Laboratories
Description: AZIDO-L-PHENYLALANINE (CCT-1406) 25G

New Product


Catalog Number: (102870-976)
Supplier: R&D Systems
Description: CCT 018159 (10 MG)


Catalog Number: (103759-316)
Supplier: R&D Systems
Description: RAC-CCT 250863 POTENT NEK2 INHIBITOR 5MG


Catalog Number: (103756-858)
Supplier: R&D Systems
Description: CCT 241533 DIHYDROCHLORIDE >/=98% 10MG


Catalog Number: (77219-090)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit monoclonal [ARC2098] antibody to CT A for WB with samples derived from Human.


Catalog Number: (76849-484)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to CCT6A for WB with samples derived from Human, Mouse and Rat.


Catalog Number: (77056-730)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to CCT6A for IHC and ELISA with samples derived from Human, Mouse and Rat.


Catalog Number: (77068-806)
Supplier: ANTIBODIES.COM LLC
Description: Goat polyclonal antibody to CCT3 for ELISA, WB and IHC with samples derived from Human and Mouse.


Catalog Number: (77079-850)
Supplier: ANTIBODIES.COM LLC
Description: Goat polyclonal antibody to TCP1 for ELISA, WB, IHC, IF and Flow Cytometry with samples derived from Human.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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