You Searched For: Biotium

Supplier: Biotium

Description: MAGE A1, Monoclonal antibody, Clone: MA454, Host: Mouse, Species reactivity: Human, Dog, Rat, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Human MAGE-A1 full length recombinant protein, Synonyms: MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, Application: IF, Size: 100uL

Supplier: Biotium

Description: This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Supplier: Biotium

Description: MART-1 / Melan-A, Monoclonal antibody, Clone: A103, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Application: IF, IHC Western, Size: 500uL

Supplier: Biotium

Description: P21 / WAF1, Monoclonal antibody, Clone: CIP1/823, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2), Application: IF, IHC, Size: 100uL

Supplier: Biotium

Description: P21 / WAF1, Monoclonal antibody, Clone: DCS-60.2, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2), Application: IF, IHC, Size: 100uL

Catalog Number: (75967-172)

Supplier: Biotium

Description: This antibody recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Supplier: Biotium

Description: P27 / KIP1, Monoclonal antibody, Clone: KIP1/769, Host: Mouse, Species reactivity: Mouse, Monkey, Rat, Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Mouse recombinant p27 protein (DCS-72.F6), Synonyms: CDKN1B, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Size: 100uL

Supplier: Biotium

Description: P24-HIV, Monoclonal antibody, Clone: p24/661, Host: Mouse, Species reactivity: HIV Type 1, Isotype: IgG2b, kappa, Conjugate: CF647, Immunogen: Recombinant HIV-1 Gag p24 protein, Synonyms: Capsid protein p24; Human immunodeficiency virus type 1 p24, Application: IHC, Size: 500uL

Supplier: Biotium

Description: P53, Monoclonal antibody, Clone: BP53-12, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF594, Immunogen: Recombinant human TP53 protein, Synonyms: Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, Application: IF, IHC (formalin), Western, Size: 500uL

Supplier: Biotium

Description: P34 / cdk1, Monoclonal antibody, Clone: POH-1, Host: Mouse, Species reactivity: Human, Mink, Monkey, Cow, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant human CDK1 protein, Application: Immunofluorescence, Immunohistology (formalin), Flow, Size: 100uL

Supplier: Biotium

Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: (75967-564)

Supplier: Biotium

Description: P53, Monoclonal antibody, Clone: BP53-12, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, BSA-free, Immunogen: Recombinant human TP53 protein, Synonyms: Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, Application: IF, IHC (formalin), Western, Size: 50 uL

Supplier: Biotium

Description: P57 / KIP2, Monoclonal antibody, Clone: KIP2/880, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human p57Kip2 protein, Synonyms: Beckwith Wiedemann syndrome (WBS); BWCR, Application: IF, IHC, Size: 500uL

Supplier: Biotium

Description: P55;50 EBV-Early Antigen, Monoclonal antibody, Clone: 1108-1, Host: Mouse, Species reactivity: EBV, Isotype: IgG1, kappa, Conjugate: CF568, Synonyms: EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1, Application: Immunofluorescence, Size: 100uL

Supplier: Biotium

Description: This antibody recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.