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Supplier: Biotium

Description: The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: MART-1 / Melan-A, Monoclonal antibody, Clone: M2-9E3, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Application: IF, IHC Western, Size: 100uL

Supplier: Biotium

Description: MHC II (HLA-DRA), Monoclonal antibody, Clone: 19-26.1, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgM, kappa, Conjugate: CF488A, Immunogen: Spleen cells of a patient with hairy cell leukemia (Daudi cells), Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

Description: In Western blotting, this antibody recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of EMA. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Catalog Number: (75963-682)

Supplier: Biotium

Description: This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

Catalog Number: (75964-022)

Supplier: Biotium

Description: Mucin 1 / EMA / Episialin / CD227, Monoclonal antibody, Clone: VU-2G7, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, BSA-free, Immunogen: Human milk-fat globule membranes (HMFGM), Application: IF, Size: 50 uL

Supplier: Biotium

Description: MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MUC18/1130, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF594, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Supplier: Biotium

Description: MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: OJ79c, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: biotin, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow cytometry, Size: 500uL

Supplier: Biotium

Description: MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MUC18/1130, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF568, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Supplier: Biotium

Description: MyoD1, Monoclonal antibody, Clone: 5.8A, Host: Mouse, Species reactivity: Mouse, Rat, Human, Chicken, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant mouse MyoD1 protein, Synonyms: bHLHc1, Application: IF, IHC (formalin), Flow, Size: 500uL

Catalog Number: (75964-732)

Supplier: Biotium

Description: MyoD1, Monoclonal antibody, Clone: 5.8A, Host: Mouse, Species reactivity: Mouse, Rat, Human, Chicken, Isotype: IgG1, kappa, BSA-free, Immunogen: Recombinant mouse MyoD1 protein, Synonyms: bHLHc1, Application: Immunofluorescence, IHC (formalin), Flow, Size: 50 uL

Supplier: Biotium

Description: MyoD1, Monoclonal antibody, Clone: 5.8A, Host: Mouse, Species reactivity: Mouse, Rat, Human, Chicken, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant mouse MyoD1 protein, Synonyms: bHLHc1, Application: IF, IHC (formalin), Flow, Size: 100uL

Supplier: Biotium

Description: This antibody recognizes a phosphor-protein of 45 kDa, identified as MyoD1. This MAb does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.

Supplier: Biotium

Description: This antibody recognizes a phosphor-protein of 45 kDa, identified as MyoD1. This MAb does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.

Supplier: Biotium

Description: Neurofilament (H+L), Monoclonal antibody, Clone: NF421 + NFL736, Host: Mouse, Species reactivity: Mouse, Pig, Rat, Human, Chicken, Isotype: IgG's, Conjugate: CF405S, Immunogen: Recombinant human neurofilament heavy sub-unit (RT-97) & light sub-unit (NR-4), Size: 100uL

Supplier: Biotium

Description: Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.