You Searched For: Anisomycin

Supplier: Ambeed

Description: Anisomycin ≥98%

New Product

Catalog Number: (AAJ67498-XF)

Supplier: Thermo Scientific Chemicals

Description: Anisomycin is applied as an antiparasitic agent and antineoplastic agent.

SDS Certificates

Catalog Number: (89164-784)

Supplier: Enzo Life Sciences

Description: Activator of MAPK, Jnk and p38

Supplier: TCI America

Description: Anisomycin also termed as Flagecidin, inhibitor and anoikis sensitizer that functions by decreasing FLIP protein synthesis.

SDS

Catalog Number: (103486-812)

Supplier: Affymetrix, Inc.

Description: Predicted to react with bovine, chicken, dog, monkey, mouse and zebrafish based on sequence homology. For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM NaF should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background. In Western blot, this antibody detects a band at ~39kDa in Western blots of anisomycin C-6 glioma cell lysates. p38 MAPK is a serine/threonin kinase which plays an important role in signal transduction, contributing to the regulation of many cellular processes including cell differentiation and inflammation. The protein is activated by phosphorylation of threonine 180 and tyrosine 182, by serveral upstream kinases, in response to a wide range of extracellular stimuli such as UV B irradiation and endotoxin exposure.

Catalog Number: (75815-000)

Supplier: Hardy Diagnostics

Description: BCYE Selective Agar is for the selective isolation of Legionella spp.

Certificates

Supplier: Enzo Life Sciences

Description: Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor
>A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8nM) in an ATP-competitive and irreversible manner; also inhibits MEK1 (IC50 = 411nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) but at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells.

Catalog Number: (103416-138)

Supplier: Affymetrix, Inc.

Description: A suggested positive control for this product is Jurkat cells treated with anisomycin. p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, a, b, g and d, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor-a, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and-6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

Catalog Number: (102057-768)

Supplier: Affymetrix, Inc.

Description: The InstantOne™ ELISA is specifically engineered for accurate measurement of phosphorylated human and mouse p38 MAPK in cell lysates. Detection of rat p38 MAPK is expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate. p38 MAPKs, also known as the Stress-Activated Protein Kinases (SAPKs), are a sub-family of the JNK/SAP family of MAP Kinases. There are four isoforms of p38 MAPK, denoted alpha (SAPK2A), beta (SAPK2B), gamma (SAPK3b) and delta (SAPK4). Like ERK and JNK, p38 MAP Kinases are activated via phosphorylation of the TxY motif that corresponds to Thr180/Tyr182 for p38alpha. p38 is activated by MEK3 and MKK6 in response to cellular stresses, most notably inflammatory cytokines, irradiation, UV light, osmotic shock, lipopolysaccharides, and toxins such as anisomycin. Once activated, p38 phosphorylates numerous targets, including the transcription factors ATF2 and ELK1 and kinases such as MAPKAPK2. Thus, p38 plays a critical role in the production of cytokines including IL-6, inflammation, cancer, and neurodegenerative diseases.

Catalog Number: (102057-770)

Supplier: Affymetrix, Inc.

Description: The InstantOne™ ELISA is specifically engineered for accurate measurement of total and phosphorylated human and mouse p38 MAPK in cell lysates. Detection of rat p38 MAPK is expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate. p38 MAPKs, also known as the Stress-Activated Protein Kinases (SAPKs), are a sub-family of the JNK/SAP family of MAP Kinases. There are four isoforms of p38 MAPK, denoted alpha (SAPK2A), beta (SAPK2B), gamma (SAPK3b) and delta (SAPK4). Like ERK and JNK, p38 MAP Kinases are activated via phosphorylation of the TxY motif that corresponds to Thr180/Tyr182 for p38alpha. p38 is activated by MEK3 and MKK6 in response to cellular stresses, most notably inflammatory cytokines, irradiation, UV light, osmotic shock, lipopolysaccharides, and toxins such as anisomycin. Once activated, p38 phosphorylates numerous targets, including the transcription factors ATF2 and ELK1 and kinases such as MAPKAPK2. Thus, p38 plays a critical role in the production of cytokines including IL-6, inflammation, cancer, and neurodegenerative diseases.

Catalog Number: (102057-766)

Supplier: Affymetrix, Inc.

Description: The InstantOne™ ELISA is specifically engineered for accurate measurement of total human and mouse p38 MAPK in cell lysates. Detection of rat p38 MAPK is expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate. p38 MAPKs, also known as the Stress-Activated Protein Kinases (SAPKs), are a sub-family of the JNK/SAP family of MAP Kinases. There are four isoforms of p38 MAPK, denoted alpha (SAPK2A), beta (SAPK2B), gamma (SAPK3b) and delta (SAPK4). Like ERK and JNK, p38 MAP Kinases are activated via phosphorylation of the TxY motif that corresponds to Thr180/Tyr182 for p38alpha. p38 is activated by MEK3 and MKK6 in response to cellular stresses, most notably inflammatory cytokines, irradiation, UV light, osmotic shock, lipopolysaccharides, and toxins such as anisomycin. Once activated, p38 phosphorylates numerous targets, including the transcription factors ATF2 and ELK1 and kinases such as MAPKAPK2. Thus, p38 plays a critical role in the production of cytokines including IL-6, inflammation, cancer, and neurodegenerative diseases.

Catalog Number: (102854-640)

Supplier: Cell Signaling Technology

Description: 2222S ANISOMYCIN-10 MG

Catalog Number: (76344-998)

Supplier: RPI

Description: ANISOMYCIN -STREPTOMYCES GRISEOLUS 500MG

Catalog Number: (MSPP-HY1898210)

Supplier: MEDCHEMEXPRESS LLC MS

Description: DMSO ANISOMYCIN SOLUTION 10 MM 1 ML

Catalog Number: (MSPP-HY1898)

Supplier: MEDCHEMEXPRESS LLC MS

Description: INHIBITOR ANISOMYCIN 99.4% 10MM 1ML DMSO

New Product

Catalog Number: (100505-784)

Supplier: R&D Systems

Description: ANISOMYCIN 10MG