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Product Image-76015-552

Self-Masking Semi-Micro Cuvettes with PTFE Stopper, FireflySci

Supplier: FIREFLYSCI, INC.
Description: Two windows polished.

Image Unavailable-EM-AX0116-NP20

Acetone ≥99.5% (by GC, corrected for water content), OmniSolv®, Supelco®

Supplier: THOMAS SCIENTIFIC INC MX
Description: For spectrophotometry, chromatography, and residue analysis.

SDS Certificates Environmentally Preferable

Product Image-76510-296

GenScript® Magnetic Beads for Protein and Antibody Purification

Catalog Number: (76510-296)
Supplier: Genscript
Description: To enable fast and efficient purification of antibody and epitope-tagged proteins, GenScript provides super paramagnetic magnetic beads. GenScript magnetic beads are coated with recombinant protein ligands that enable highly specific affinity binding to antibodies and epitope-tagged proteins.
Product Image-RCRV010683100N

VeriSpec® ICP Multi-Element Standard 10, RICCA Chemical Company

Catalog Number: (RCRV010683100N)
Supplier: Ricca Chemical
Description: 10 component standard.
Image Unavailable-10237-022

Anti-ATF2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10237-022)
Supplier: Bioss
Description: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Image Unavailable-10237-030

Anti-ATF2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10237-030)
Supplier: Bioss
Description: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Image Unavailable-77902-044

AG-120 (Ivosidenib) 99%

Supplier: Ambeed
Description: AG-120 (Ivosidenib) 99%

New Product

Image Unavailable-10235-468

Anti-IRS4 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10235-468)
Supplier: Bioss
Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Image Unavailable-EM1.18338.0001

Accessories for Turbiquant®

Supplier: MilliporeSigma
Description: In addition to spare cuvettes and light sources, the pour and flow cells have been developed to improve efficiency. The pour through assembly provides a single one-time cuvette alignment and simplified rinsing.

Product Image-76016-350

Macro Laser Absorption Cell with PTFE Stopper (Lightpath: 30 to 60 mm), Type 87

Supplier: FIREFLYSCI, INC.
Description: Firefly's laser absorption cell.

Product Image-76016-408

Micro Fluorescence Cuvettes with PTFE Cover, FireflySci

Supplier: FIREFLYSCI, INC.
Description: High-quality micro cuvettes with fluorescence micro capacities and are a great value.

Product Image-89199-654

Tissue-Tek® Accu-Edge® Grossing Stations, Sakura Finetek

Supplier: Sakura Finetek
Description: Accu-Edge® Grossing Stations offer the opportunity to customize a grossing station to fit any laboratory's specific requirements

Product Image-10233-144

Anti-IRS4 Rabbit Polyclonal Antibody

Catalog Number: (10233-144)
Supplier: Bioss
Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Image Unavailable-10235-472

Anti-IRS4 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10235-472)
Supplier: Bioss
Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Image Unavailable-10235-476

Anti-IRS4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10235-476)
Supplier: Bioss
Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Product Image-10803-990

VWR® Specimen Containers with Dual Click

Supplier: VWR International
Description: The VWR® Dual Click line of specimen containers are manufactured from virgin medical grade propylene, and the Dual Click design features two audible and tactile “clicks” to let the user know the lid is properly secured.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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