You Searched For: Akt-I-1


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Supplier: Adipogen
Description: The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, Akt-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.

Supplier: Adipogen
Description: The compound (Akt-I-2) inhibited both Akt1 and Akt2 with IC(50) values of 2.7 and 21 µM respectively. It does not inhibit AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 and AKT2 isoforms, AKT-I-1,2 blocked the phosphorylation and activation of AKT1 and AKT2 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.

Supplier: Enzo Life Sciences
Description: Potent inhibitor of Akt1, Akt2 and Akt3 activity.

Catalog Number: (80016-856)
Supplier: MilliporeSigma
Description: Akti-1/2; 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one

Catalog Number: (76710-318)
Supplier: AFG BIOSCIENCE LLC
Description: Rat Phospho-Akt (P-Akt) ELISA Kit


Catalog Number: (103255-332)
Supplier: RevMAb Biosciences
Description: This antibody reacts to Akt only when phosphorylated at Ser473. There is no cross-reactivity with Akt without phosphorylation at Ser473. This antibody may also react to bovine, mouse or rat Phospho-Akt (Ser473), as predicted by immunogen homology


Catalog Number: (89304-112)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to Akt (Phospho Ser473)


Catalog Number: (77511-028)
Supplier: AFG BIOSCIENCE LLC
Description: Human Phospho AKT S473 (p-AKT) ELISA Kit

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Catalog Number: (77553-962)
Supplier: Sino Biological
Description: The AKT (SGK) Substrate peptide sequence (RPRAATF) is based on the N-terminus of GSK3.

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Catalog Number: (89367-214)
Supplier: Genetex
Description: AKT (Protein Kinase B, PKB) was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.


Catalog Number: (RL100-401-401)
Supplier: Rockland Immunochemical
Description: Primary Rabbit Anti-AKT Reacts with Chicken, Human, Mouse, Rat


Catalog Number: (RL000-000-401)
Supplier: Rockland Immunochemical
Description: control peptide when used with anti-Anti-AKT to block specific interaction of anti-AKT with AKT

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Catalog Number: (101650-674)
Supplier: MilliporeSigma
Description: Anti-AKT Rabbit Polyclonal Antibody

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Catalog Number: (76713-694)
Supplier: AFG BIOSCIENCE LLC
Description: Human Phospho-Akt(P-Akt) ELISA Kit


Catalog Number: (89317-512)
Supplier: Genetex
Description: Purity: This antiserum is directed against AKT and reacts with the AKT from human tissues. Species Reactivity: Human Tested Applications: ELISA, WB Pkg Size: 50 ug


Catalog Number: (RL000-000-260)
Supplier: Rockland Immunochemical
Description: Primary Anti-AKT/PKBa Reacts with Pan

Small Business Enterprise Minority or Woman-Owned Business Enterprise


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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