Print…

You Searched For: ALPHA+RHO,+INC.


96,489  results were found

Refine Results Sort by
SearchResultCount:"96489"

Sort Results

List View Easy View

Rate These Search Results

Image Unavailable-77439-676

Anti-PAR-2 Rabbit Polyclonal Antibody

Catalog Number: (77439-676)
Supplier: Bioss
Description: Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
Image Unavailable-75844-614

Y-27632 dihydrochloride ≥98%

Supplier: BIOGEMS INTERNATIONAL INC.
Description: Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).

Image Unavailable-10469-334

Anti-RACGAP1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10469-334)
Supplier: Bioss
Description: Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Image Unavailable-10469-352

Anti-RACGAP1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10469-352)
Supplier: Bioss
Description: Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Image Unavailable-102215-768

Anti-GABA-A R rho 1 Rabbit Polyclonal Antibody

Catalog Number: (102215-768)
Supplier: Novus Biologicals
Description: The GABA-A R rho 1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to GABA-A R rho 1. This antibody reacts with human. The GABA-A R rho 1 Antibody has been validated for the following applications: Western Blot.
Product Image-10731-642

Anti-RHO Rabbit Polyclonal Antibody

Catalog Number: (10731-642)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against synthetic peptide of RHO.
Image Unavailable-10469-326

Anti-RACGAP1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10469-326)
Supplier: Bioss
Description: Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Image Unavailable-10469-332

Anti-RACGAP1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10469-332)
Supplier: Bioss
Description: Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Product Image-10104-936

Anti-RACGAP1 Rabbit Polyclonal Antibody

Catalog Number: (10104-936)
Supplier: Prosci
Description: Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC, and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.
Image Unavailable-89352-874

Anti-RHO Rabbit Polyclonal Antibody

Catalog Number: (89352-874)
Supplier: Genetex
Description: Rabbit polyclonal to Rho
Product Image-10104-124

Anti-ARHGAP28 Rabbit Polyclonal Antibody

Catalog Number: (10104-124)
Supplier: Prosci
Description: ARHGAP28 contains 1 Rho-GAP domain. ARHGAP28 is a GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Image Unavailable-10338-530

Anti-ARHGEF2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10338-530)
Supplier: Bioss
Description: GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
Product Image-89147-880

Rockout ≥98% (by HPLC)

Catalog Number: (89147-880)
Supplier: Enzo Life Sciences
Description: A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC50=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632.
Product Image-76706-400

Human Homolog Gene Family, Memmber A(Rho-A) ELISA Kit

Catalog Number: (76706-400)
Supplier: AFG BIOSCIENCE LLC
Description: 36246968
Image Unavailable-10430-504

Anti-Rho GTPase activating protein 29 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10430-504)
Supplier: Bioss
Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Image Unavailable-10270-178

Anti-GABRR2 Rabbit Polyclonal Antibody

Catalog Number: (10270-178)
Supplier: Bioss
Description: Gamma-aminobutyric acid (GABA) receptors are pentameric membrane proteins that operate GABA-gated chloride channels and inhibit neurotransmission in the central nervous system. The rho receptor subunits do not exhibit sensitivity to typical GABA receptor modulators such as bicuculline, hexobarbital, and diazepam. While the rho 1 subunit localizes specifically to the retina, rho 2 expresses in all regions of the brain, though levels were still highest in the retina, implying a role for both subunits in visual pathways.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
49 - 64 of 96,489
no targeter for Bottom