You Searched For: (R)-Roscovitine


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Supplier: Enzo Life Sciences
Description: CDK inhibitor

Supplier: Ambeed
Description: (R)-Roscovitine 98%

Catalog Number: (89149-430)
Supplier: Enzo Life Sciences
Description: CDK1 inhibitor


Supplier: MilliporeSigma
Description: A potent and selective inhibitor of cyclin-dependent kinases (cdks) that exhibits about ten-fold greater efficacy towards p34cdc2 and p33cdk2, and twenty-fold greater efficacy towards p33cdk5 relative to olomoucine (80053-494, -496)
Supplier: Adipogen
Description: (S)-enantiomer of (R)-roscovitine . Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking hypoxia-induced apoptosis in neurons. Potential anti-inflammatory compound. Potential antidiabetic compound.

Supplier: Adipogen
Description: Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.

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Catalog Number: (102987-460)
Supplier: Adipogen
Description: Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.


Supplier: Sino Biological
Description: (R)-Roscovitine >99% (by TLC, NMR)

New Product

Catalog Number: (80050-952)
Supplier: MilliporeSigma
Description: Set contains 5mg of olomoucine (80053-496), 1mg of iso-olomoucine (80053-498), and 1mg of roscovitine (80054-314)

Supplier: Adipogen
Description: Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase.

Catalog Number: (89147-796)
Supplier: Enzo Life Sciences
Description: Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine.


Supplier: Ambeed
Description: (R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol, Purity: 97%, CAS Number: 866893-90-5, Appearance: Form: powder, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20C, Size: 10MG

Supplier: Adipogen
Description: Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).

Catalog Number: (77872-401)
Supplier: Ambeed
Description: (R)-ROSCOVITINE 250MG

New Product


Catalog Number: (103949-058)
Supplier: ASTATECH INC MS
Description: ROSCOVITIN 0.25G

Blocked

Catalog Number: (103949-060)
Supplier: ASTATECH INC MS
Description: ROSCOVITIN 1G

Blocked

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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