Aftin-5 ≥98% (by NMR)

Supplier: ADIPOGEN CORP MS

Irritant Warning

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Synonyms: (2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol, Amyloidβ Forty-Two Inducer 5

AG-MR-C0015-M001 AG-MR-C0015-M005 AG-MR-C0015-M025

102981-184EA 90 USD

102981-184 102981-186 102981-188

Aftin-5 ≥98% (by NMR)

Aftin-5

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).

Formula: C19H26N6O
MW: 354.5 g/mol
Storage Temperature: Freezer

CAS Number: 1461717-05-4

Specification Test Results

Purity	98% (NMR)
Appearance/Color	White to off-white solid.
Solubility	Soluble in DMSO or ethanol.

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