Phorbol-12-myristate-13-acetate, Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: TPA, Phorbol 12-myristate 13-acetate, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate

524400-25MG 524400-1MG 524400-5MG 524400-10MG

80055-402EA 769.37 USD

80055-402 80055-400 80055-404 80055-398

Phorbol-12-myristate-13-acetate, Sigma-Aldrich®

Phorbol-12-myristate-13-acetate

Most commonly-used phorbol ester

Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the FAS antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.

Formula: C₃₆H₅₆O₈
MW: 616.836 g/mol

MDL Number: MFCD00036736
CAS Number: 16561-29-8

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