Colistin Sulphate (from Bacillus polymyxa)

Supplier: ADIPOGEN CORP MS

AG-CN2-0065-M100 AG-CN2-0065-G001 AG-CN2-0065-G005
102987-208EA 41.54 USD
102987-208 102987-210 102987-212
Colistin Sulphate (from Bacillus polymyxa)
Proteins and Peptides

Very potent polymyxin antibiotic


  • Antimicrobial


Has only one amino acid difference compared to polymyxin B. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.

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