GLPG0634 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide, Filgotinib

SYN-1158-M001 SYN-1158-M005 SYN-1158-M010

102992-442EA 283.85 USD

102992-442 102992-444 102992-446

GLPG0634 ≥95%

Filgotinib (GLPG0634)

GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6.

Formula: C₂₁H₂₃N₅O₃S
MW: 425.5 g/mol
Storage Temperature: Freezer

MDL Number: MFCD20527867
CAS Number: 1206161-97-8

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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