SGX-523 ≥95%
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
6-((6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)quinoline
SYN-1155-M001
SYN-1155-M005
SYN-1155-M010
SYN-1155-M050
102992-418EA
149.54
USD
102992-418
102992-420
102992-422
102992-424
SGX-523 ≥95%
SGX-523
SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase.
Formula:
C₁₈H₁₃N₇S MW: 359.41 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD16660190 CAS Number: 1022150-57-7 |
Specification Test Results
Purity | >95% |
Appearance/Color | Solid. |
Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
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