SGX-523 ≥95%

Supplier: ADIPOGEN CORP MS
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Synonyms: 6-((6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)quinoline

SYN-1155-M001 SYN-1155-M005 SYN-1155-M010 SYN-1155-M050
102992-418EA 149.54 USD
102992-418 102992-420 102992-422 102992-424
SGX-523 ≥95%
SGX-523

SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase.

Formula: C₁₈H₁₃N₇S
MW: 359.41 g/mol
Storage Temperature: Freezer
MDL Number: MFCD16660190
CAS Number: 1022150-57-7

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Specification Test Results

Purity >95%
Appearance/Color Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.

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