Pelitinib ≥95%
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide, (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide, EKB 569, Pelitinib, (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-dimethylamino-2-butenamide
Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.
Formula:
C₂₄H₂₃ClFN₅O₂ MW: 467.92 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD09837868 CAS Number: 257933-82-7 |
Specification Test Results
Purity |
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Appearance/Color | Solid. |
Solubility | Soluble in DMSO or ethanol. |
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