GNE-490 ≥95%

Supplier: ADIPOGEN CORP MS

SYN-1114-M001 SYN-1114-M005 SYN-1114-M010

102992-134EA 283.85 USD

102992-134 102992-136 102992-138

GNE-490 ≥95%

GNE-490

GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced potency mTOR while maintaining effective potency for PI3K substrates. IC(50) values for PI3K family members are in the subnanomolar to low nanomolar range (-.28 to 20nm) while IC(50) values for mTOR and other related tyrosine kinases are greater than 750nM with most being greater than 1µM or more, thus GNE-490 makes a good choice for examining PI3K related events separate from those mediated by mTOR.

Formula: C₁₈H₂₂N₆O₂S
Storage Temperature: Freezer

CAS Number: 1033739-92-2

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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