Afatinib ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide, BIBW2992, Tovok

SYN-1100-M001 SYN-1100-M005 SYN-1100-M010 SYN-1100-M050

102992-040EA 119.08 USD

102992-040 102992-042 102992-044 102992-046

Afatinib ≥95%

Afatinib

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.

Formula: C₂₄H₂₅ClFN₅O₃
MW: 485.94 g/mol
Storage Temperature: Freezer

MDL Number: MFCD12407405
CAS Number: 850140-72-6

Specification Test Results

Purity	>95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO or ethanol.

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