Danusertib ≥95%
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
PHA-739358, (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to
Formula:
C₂₆H₃₀N₆O₃ MW: 474.6 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD12024692 CAS Number: 827318-97-8 |
Specification Test Results
Purity |
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Appearance/Color | Solid. |
Solubility | Soluble in DMSO or ethanol. |
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