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Danusertib ≥95%

Supplier: ADIPOGEN CORP MS

Irritant Warning

Warning

SYN-1095-M001 SYN-1095-M005 SYN-1095-M010 SYN-1095-M050

102992-004EA 156.46 USD

102992-004 102992-006 102992-008 102992-010

Danusertib ≥95%

Danusertib

Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to 200nM.

Formula: C₂₆H₃₀N₆O₃
Storage Temperature: Freezer

MDL Number: MFCD12024692
CAS Number: 827318-97-8

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO or ethanol.

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