SB242235 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine, SB 242235, 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine

SYN-1076-M001 SYN-1076-M005 SYN-1076-M010
102991-856EA 283.85 USD
102991-856 102991-858 102991-860
SB242235 ≥95%
SB242235

The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. SB-242235 is a potent and moderately selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. SB-242235 exhibits good oral availability in preclinical studies and has micromolar or submicomolar in vivo IC(50) values. However it is clear from studies examining SB-242235 effects on metabolism, for instance in chondrocytes and human cartilage that SB-242235 effects can be pleiotropic between species and that care must be taken when studying the interactions of multi-target inhibitors such as SB-242235.

Formula: C₁₉H₂₀FN₅O
MW: 353.4 g/mol
Storage Temperature: Freezer
MDL Number: MFCD08690575
CAS Number: 193746-75-7

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

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