Merck-5 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: Pyridone 6, 2-(tert-Butyl)-9-fluoro-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one, JAK Inhibitor

SYN-1054-M001 SYN-1054-M005 SYN-1054-M010

102991-670EA 292.15 USD

102991-670 102991-672 102991-674

Merck-5 ≥95%

Merck-5

Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) 100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5. In research comparing Merck 5 (Pyridone 6) to the Jak inhibitor AG490, Merck 5 demonstrated much lower effective drug concentrations and faster kinetics and appear to be a more sensitive and specific inhibitor of JAK-STAT3 activity compared with AG490 and potently inhibited the growth of primary myeloma cells and myeloma-derived cell lines grown on bone marrow-derived stromal cells .

Formula: C₁₈H₁₆FN₃O
MW: 309.3 g/mol
Storage Temperature: Freezer

MDL Number: MFCD17019334
CAS Number: 457081-03-7

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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