BEZ235 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile, NVP-BEZ235, Dactolisib

SYN-1018-M001 SYN-1018-M005 SYN-1018-M010 SYN-1018-M050

102991-384EA 90 USD

102991-384 102991-386 102991-388 102991-390

BEZ235 ≥95%

BEZ235

NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.

Formula: C₃₀H₂₃N₅O
MW: 469.6 g/mol
Storage Temperature: Freezer

MDL Number: MFCD10565944
CAS Number: 915019-65-7

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO or ethanol.

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