AMG-47a ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide

SYN-1007-M001 SYN-1007-M005 SYN-1007-M010
102991-302EA 292.15 USD
102991-302 102991-304 102991-306
AMG-47a ≥95%
AMG-47a

The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. AMG-47 is one of two optimized chemical compounds that has been shown to be extremely effective in vivo and in vitro in inhibiting Lck as well as a number of other receptor tyrosine kinases. In an anti-CD3/ IL-2 mouse model system AMG-47 has been shown to be effective in inhibiting the Lck mediated anti-inflammatory activity (ED50 11 mg/kg; 630nM) in vivo. In multiple other in vitro assays, AMG-47 exhibits subnanomolar inhibition against Lck, and low (10nM) inhibition against other hard to inhibit kinases such as KDR and SRC and MAPK alpha (p38alpha). Moreover at slightly higher doses but well under 10µM, AMG-47 effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2µM.

Formula: C₂₉H₂₈F₃N₅O₂
MW: 535.6 g/mol
Storage Temperature: Freezer
MDL Number: MFCD09970318
CAS Number: 882663-88-9

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

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