ABT-737 ≥95%

Supplier: ADIPOGEN CORP MS

Irritant Warning

Warning

SYN-1001-M005 SYN-1001-M010 SYN-1001-M050 SYN-1001-M001

102991-174EA 134.31 USD

102991-174 102991-176 102991-178 102991-292

ABT-737 ≥95%

ABT-737

ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki 1 nM) and also shows a very high specificity over Mcl-1 and A1.

Formula: C₄₂H₄₅ClN₆O₅S₂
Storage Temperature: Freezer

MDL Number: MFCD12756212
CAS Number: 852808-04-9

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO. Slightly soluble (1mg/ml) in ethanol.

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