5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione ≥95% (by HPLC)

Supplier: ADIPOGEN CORP MS

Synonyms: Pim1/2 Inhibitor IV, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione

CDX-P0110-M005 CDX-P0110-M010 CDX-P0110-M050
102990-834EA 131.54 USD
102990-834 102990-836 102990-838
5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione ≥95% (by HPLC)
5-[(4-Propyloxyphenyl)methylene]-2,4-thiazolidinedione (SMI-16a)

Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).

Formula: C₁₃H₁₃NO₃S
MW: 263.31 g/mol
Storage Temperature: Freezer
MDL Number: MFCD31382191
CAS Number: 587852-28-6

Order Now

Specification Test Results

Source/Host Synthetic
Purity 95% (HPLC)
Appearance/Color Yellow powder.
Solubility Soluble in DMSO.

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR