N-Dodecanoyl-DL-homoserine lactone ≥97% (by GC)
Supplier: ADIPOGEN CORP MS
Synonyms:
C12-HSL
N-Dodecanoyl-DL-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It also was shown to induce cell death by apoptosis.
Formula:
C₁₆H₂₉NO₃ MW: 283.4 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD03100412 CAS Number: 18627-38-8 |
Specification Test Results
Source/Host | Synthetic. |
Purity |
|
Appearance/Color | White solid. |
Solubility | Soluble in chloroform. |
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