N-Dodecanoyl-L-homoserine lactone ≥98% (by NMR)
Supplier: ADIPOGEN CORP MS
Synonyms:
(S)-N-(2-Oxotetrahydrofuran-3-yl)dodecanamide, N-[(3S)-Tetrahydro-2-oxo-3-furanyl]-dodecanamide
N-Dodecanoyl-L-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.
Formula:
C₁₆H₂₉NO₃ MW: 283.4 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD11976890 CAS Number: 137173-46-7 |
Specification Test Results
Source/Host | Synthetic. |
Purity |
|
Appearance/Color | White powder. |
Solubility | Soluble in DMSO and dimethylformamide (approx. 30mg/ml). |
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