Aftin-4 ≥98% (by HPLC)

Supplier: ADIPOGEN CORP MS
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Synonyms: N6-Methyl-(R)-roscovitine, (R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

AG-MR-C0014-M001 AG-MR-C0014-M005 AG-MR-C0014-M025
102988-830EA 76.15 USD
102988-830 102988-832 102988-834
Aftin-4 ≥98% (by HPLC)
Aftin-4

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase.

Formula: C₂₀H₂₈N₆O
MW: 368.5 g/mol
Storage Temperature: Freezer
MDL Number: MFCD30187584
CAS Number: 866893-90-5

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Specification Test Results

Purity 98% (HPLC)
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO or ethanol.

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