MCC950 sodium salt ≥98% (by HPLC)
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
MCC950, MCC950 sodium, Sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulphonyl)amide
Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production of IL-1beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). Also active in ex vivo samples from individuals with Muckle-Wells syndrome. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
Formula:
C₂₀H₂₃N₂NaO₅S MW: 426.5 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD30478884 CAS Number: 256373-96-3 |
Specification Test Results
Purity |
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Appearance/Color | Crystalline solid. |
Solubility | Soluble in water, DMSO, dimethyl formamide or ethanol. |
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