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Epoxomicin ≥97% (by NMR)

Supplier: ADIPOGEN CORP MS

AG-CN2-0422-C050 AG-CN2-0422-C100 AG-CN2-0422-C250 AG-CN2-0422-C500

102988-220EA 96.92 USD

102988-220 102988-222 102988-224 102988-226

Epoxomicin ≥97% (by NMR)

Epoxomicin

Antibiotic

Source/Host: Synthetic.
Purity: >97% (NMR)
Appearance/Color: White to off-white solid.
Solubility: Soluble in DMSO. Insoluble in water.

Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy.

Formula: C₂₈H₅₀N₄O₇
Storage Temperature: Freezer

MDL Number: MFCD03791061
CAS Number: 134381-21-8

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