Ascomycin ≥98%, high purity

Supplier: ADIPOGEN CORP MS
Warning

Synonyms: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

AG-CN2-0420-M001 AG-CN2-0420-M005 AG-CN2-0420-M025
102988-212EA 41.54 USD
102988-212 102988-214 102988-216
Ascomycin ≥98%, high purity
Ascomycin

Macrolide antibiotic


Source/Host: Isolated from Streptomyces sp.
Purity: >98%
Appearance/Color: White to off-white solid.
Solubility: Soluble in DMSO or ethanol.


Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic).

Formula: C₄₃H₆₉NO₁₂
MW: 790 g/mol
Storage Temperature: Freezer
MDL Number: MFCD06198665
CAS Number: 104987-12-4

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