Okadaic acid ammonium salt ≥98% (by HPLC), high purity
Supplier: ADIPOGEN CORP MS
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Danger
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Synonyms:
Halochondrine A ammonium salt, OA
Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization.
Formula:
C₄₄H₆₇O₁₃·NH₄ MW: 822.03 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00153856 CAS Number: 155716-06-6 UN: 3462 ADR: 6.1,III |
Specification Test Results
Source/Host | Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. |
Purity | >98% (HPLC) |
Appearance/Color | White to off-white solid. |
Solubility | Soluble in DMSO, ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water. |
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